Five men, all born on a Saturday the 5th, are adopted by Apichai and trained to become immortals. Each has a unique power: Diao hears distant voices, Thoed becomes invisible when holding his breath, Don travels through space in meditation, Yod walks through any barrier, and Kring moves fast and can shape-shift.

Their mission: stop the Jarga group, who stole a deadly disease bomb from Europe and hid it in Thailand. They're joined by Apichai's daughter, Bussakorn, an expert on the weapon, and Duangkamol, an undercover investigator.